We specialize in understanding mechanisms regulating gut homeostasis in health and disease with a specific interest in how epithelial cells respond to damage and inflammation. We employ in vivo models and 3D organoid cultures (enteroids, colonoids) from mice and humans to understand the molecular and cellular basis of tissue regeneration and inflammatory bowel disease (IBD). Within these contexts, we study how RNA-binding proteins impart post-transcriptional regulation of key pathways in normal physiology and disease.
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