Basic and translational gastrointestinal research  

The Hamilton lab studies epithelial cells in the gastrointestinal tract and the roles they play in human health, regenerative medicine, and inflammatory bowel disease. Epithelial cells are particularly important because they form a barrier between the external environment and the rest of the body. A breakdown of this barrier is a hallmark of gastrointestinal injury and disease. While we understand a great deal about the function of gastrointestinal epithelial cells, there is paucity of strategies to heal the barrier by directly targeting epithelial cells. Our goal is to identify new mechanisms of gastrointestinal epithelial cell behavior that can serve as new therapeutic targets for patients suffering from gastrointestinal diseases.

Generating foundational knowledge of human health 

Our goal is to generate foundational discoveries to advance human health and alleviate suffering from disease.

Training the next generation of scientists​

We are committed to and are actively involved in training the next generation of the scientific workforce.

This is the personal website of Dr. Kathryn (Kate) Hamilton. The Hamilton laboratory is grateful to our funding sources: National Institutes of Health; the Lisa Dean Moseley Foundation; the The Leona M. and Harry B. Helmsley Charitable Trust; Crohn’s and Colitis Foundation; the University of Pennsylvania Institute for Translational Medicine (ITMAT); the University of Pennsylvania Institute for Regenerative Medicine; and the Children's Hospital of Philadelphia (CHOP) Research Institute Development Funds. Banner graphic designed by Arwa Abbas.

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If you would like to support research in the Hamilton lab, please contact Dr. Hamilton via the Contact tab.